Method of production of drugs: lyophilized powder for making Mr injection of 300 OD in the amp. symptoms of ischemia, which rapidly improved, or are minimal before infusion, severe stroke on clinical inspected and / or determined by appropriate imaging techniques, cramps in the event of symptoms of stroke, presence of previous stroke or a severe head wound during the last 3 months, the combination of the previous stroke and diabetes, the introduction of heparin within the last 48 hours prior to stroke with increased ACHTCH during a patient to a hospital, the number of platelets less than 100,000 / mm3, systolic arterial pressure> 185 or diastolic blood pressure> 110 mmHg, or active drug intervention (in / in) order to reduce the antibodies to these limits; blood glucose <50 or> 400 mg / dL, not intended for treatment of stroke g in children and adolescents under 18 years in adults older than 80 years. The main pharmaco-therapeutic effects: antytrombichna. Side effects of drugs and complications in the use of drugs: AR - hyperemia of face, hives, with subkon'yunktyvalnomu possible introduction of the drug injection site pain that quickly passes. Dosing and Administration of drugs: injected pidkon'yunktyvalno - contents of capsules dissolve Shunt Fraction 0.5 ml water for injection, Mr Shortness of Breath (Dyspnea) conjunctiva or sclera transitional fold lower after previous anesthesia by instillation in the conjunctival sac 0 5% to Mr dykayinu; repeated injections inspected in 1-2 days, the total number of injections - from 3 to 10 (900 - 3 500 units). Method of production of drugs: lyophilized powder for making Mr infusion 50 mg vial. Indications for use drugs: Thrombolytic treatment d. Contraindications to the use of drugs: the case of high inspected of bleeding - much bleeding, existing or has occurred over the past six months, revealed a hemorrhagic diathesis patients taking oral anticoagulants, a history of any CNS disease (such as tumor, aneurysm, intracranial or spinal surgery), intracranial hemorrhage, any actual or suspected Temperature including subarachnoid hemorrhage, severe uncontrolled hypertension, major surgery or major trauma in the last 10 days (it belongs to, any injury related to existing HIM G ), recently moved CCT, long or traumatic cardio-pulmonary resuscitation (> 2 min), delivery of the last 10 days, recently krovenosnyh vascular puncture, severe forms of liver dysfunction, including hepatic failure, cirrhosis, portal hypertension (esophageal varicose veins) and available hepatitis, hemorrhagic retinopathy, eg in diabetes (impaired vision may indicate hemorrhagic retinopathy), or other hemorrhagic ophthalmic disease, bacterial endocarditis, pericarditis, pancreatitis g; revealed ulcer during the past 3 months, aneurysm of the arteries, arterial / venous malformations; neoplasm inspected increased risk of bleeding, hypersensitivity to active substance - alteplaze or any excipient, by IM G and pulmonary embolism - a history of stroke, with ischemic stroke G - G ischemia symptoms began more than 3 h to alteplazy early infusion or time of occurrence of symptoms is unknown, d.
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